Clearbridge Medical ColoClear Non-Invasive Colorectal Cancer (FIT-DNA) Screening Test

Clearbridge Medical ColoClear Non-Invasive Colorectal Cancer (FIT-DNA) Screening Test Flow:

1. Customer visit Clearbridge Medica Center on the booking date; Doctor conducts health consultation & Physical examination for customer;
2. Customer will receive an ColoClear kit set, it includes a full set of stool collection samples materials and stool collection guide;
3. Customer can bring it back to home and collect samples at home flexibly;
4. Customer collect the samples and contact Clearbridge Medica Center to pick up the sample;
5. After medical reports are ready, clinic staff with contact and arrange medical result report interpretation by the doctor.

Clearbridge Medical ColoClear Non-Invasive Colorectal Cancer (FIT-DNA) Screening Test

ColoClear by Circle is a non-invasive, FIT-DNA screening test for detecting early signs of colorectal cancer using at-home sample collection. The test is designed to make colorectal cancer screening simple and convenient, so you can be proactive and in control of your health.

ColoClear detects colorectal cancer with 96% sensitivity

• A new generation of DNA technology, multi-target fecal gene (FIT-DNA) testing technology; recommended by the US Preventive Medicine Working Group
• 5 working days with report
• Detection of colorectal polyps and early colorectal cancer risk from small stool samples
• Colorectal cancer screening test approved by the National Medical Products Administration (NMPA)

Colorectal cancer is the second most common and fatal cancer in Hong Kong. In 2019, it has recorded more than 5,000 cases of colorectal cancer have been recorded, accounting for 15.8% of all cancer cases.

Colorectal cancer is one of the cancers with the best chance of being detected early—up to 90 percent of patients can be treated when detected early. In fact, one of the five people had large intestine polyps. Although most polyps are benign, there is a risk of developing cancer. Therefore, polyp detection is one of the methods that can effectively prevent colorectal cancer.

But according to 2017 data, nearly half of colorectal cancer cases are detected at an advanced stage, making treatment very difficult. Therefore, early detection is one of the most effective ways to prevent colorectal cancer.

How does ColoClear work?

The ColoClear kit includes two test tubes that each perform a different test.

One test extracts the DNA from your stool, and tests against certain biomarkers indicative of the presence of colorectal cancer and/or pre-cancerous polyps.

The other test is a standard Faecal Immunocolloid Test (FIT) that detects traces of blood in your stool, which can be indicative of colorectal cancer.

The DNA test detects altered DNA such as mutations that can indicate pre-cancerous polyps and/or colorectal cancer. A Faecal Immunocolloid Test (FIT) tests for traces of blood, which can be caused by colorectal cancer and/or pre-cancerous polyps. However, polyps or growths that bleed may not bleed all the time. For this reason, the sensitivity of a FIT test for colorectal cancer ranges from 77% - 94% when compared to screening for colorectal cancer using a colonoscopy.

The combination of these two tests increases the sensitivity for colorectal cancer detection to up to 96% by testing for multiple biomarkers.

Recommend For

• People who want to know the risk of having colorectal adenoma and colorectal cancer.
• This test is particularly beneficial for people aged over 40 who are at average or higher risk for colorectal cancer. This includes, but is not limited to individuals who have:
  - A family history of colorectal cancer
  - A medical history of malignant colorectal tumours
  - Previously suffered from intestinal polyps
  - A medical history of appendicitis and/or an appendectomy
  - Symptoms affecting the bowels (e.g. diarrhoea, constipation, bloating, bloody stool), including younger individuals (above age 18)

Not Suitable For

• You should not use a ColoClear test kit if you are experiencing any of the following conditions:
  - Menstrual bleeding
  - Diarrhoea and/or watery stool
  - Gastrointestinal/rectal bleeding (e.g. actively bleeding haemorrhoids) -
  - The conditions listed above increase the likelihood of stool sample contamination with traces of blood and/or abnormal cells that are not necessarily due to colorectal cancer. Therefore, it is best not to take this test under these conditions.
• Individuals who have been diagnosed with the following conditions should not use ColoClear
  - Familial Adenomatous Polyposis (FAP)
  - Crohn's disease
  - Inflammatory Bowel Disease (IBD) including Chronic Ulcerative Colitis (CUC)